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Garlic brief introduction
The garlic(the Allium sativum) originates Central Asia, is a spice plant that is made use of extensively, is made also
For being a traditional folks to use a medicine and canning promote healthy food of the body and mental state.Because the garlic has to the human body disease
Rather good curative effect, so all have with the garlic treatment disease in many ancient civilizations of related jot down.The earliest of
Jot down far from 5000 ago appeared namely, people used to cure the appetite way disease, parasite an infection, breath way infection,
The skin disease and general external injury.The modern research garlic mainly has anti- microorganism, anti- blood to bolt the formation, anti- tumor formation and
Reduce the blood fat content etc. curative effect.Because wears several functions that the garlic owns, till now garlic still is extensive
The plant of the usage
The garlic has of contain the sulphur composition(the organosulfur compounds) is a main curative effect source.Among them the most important
Of the composition is an Allicin(garlic vegetable), at different environment with extract under condition, can change into different valid become
Cent.(Ref 2)the Allicin also is the main source of the garlic smell.
The valid composition of the garlic
garlics are effectively the formation of the ingredients
The γ -glutamylcysteine that the garlic China has originally(is a kind of 肽, By two kinds of An Jis the sour Gu An is sour
(Glutamate)link formation with the half cysteine(cysteine))[pay respects to figure 5], will be turned to become in the mature process
The Allicin tended a thing ago and a kind of contained the sulphur composition S-allylcysteine(SAC).
The γ -glutamylcysteine is oxidized alliin(Allicin of before tend a thing) in the garlic, is broken by outside power
Hour(as rub or incise garlic?Caulis)will be function(alliinase) conversion by enzyme Allicin.And the Allicin is originally
The body is a very unsteady material, after becoming would immediately the self resolve other materials.Here in the meantime, γ
-The glutamylcysteine will walk another path change become S-allylcysteine.The Allicin will be resolved DAS
(The Diallyl sulfide), DADS(the Diallyl disulfide), the DATS(the Diallyl trisulfide) and dithiin, ajoene
Wait for other materials.Below we mainly will inquire into the S-alylcysteine(water-soluble, have important curative effect) and DAS
Type(is all material of a pair of Xi keys knot, is just the sulphur atom number contained different difference, is lipid solubility) two kinds of materials
Of function.
usage form of the garlics
The main usage form of the garlic has four as follows:Essential oil(oil), Dehydrated powder(powder),
The Oil macerate(ointment) and Extract.(extract a liquid)Among them, the AGE is most valid(Aged garlic extract
The aging garlic extracts a liquid), is water-soluble due to the above important ingredient S-allylcysteine of having the curative effect lifted
Material, so only in the middle just see in the AGE more SACs, then own more curative effect.
Have already attained a Mature(mature) stage and make it continue in the horticulture learn the top the Aged for the fruit the growth the process
"Back mature" stage of the growth.Say simply, the fruit was familiar hereafter do not dismantle to eat, continue it to stay in the plant
Grow up up, be called aging.Familiar garlic after taking these(took to use under the special conservancy condition to store here 20
Garlic of month), is because of valid composition,such as SAC, DAS etc. content, and will increase in the aging process, together
Hour the stimulative and unsteady material content will reduce.(Ref 1) use these garlics to extract a liquid if the alcohol extracts
After can immediately get AGE.
The effect and the function with 2-3 AGEs
AGE is has no color tasteless, after the indoor temperature descend from the fresh garlic( heated of garlic the valid composition encounter breakage,
Don't have curative effect)win a kind of liquid been extracted;The high living creature activity had is the shell confimation to have already been in the human body
With experiment animal in all effective, therefore the top of the clinic extensive usage.(Ref 6) the AGE be regarded as is good
The anti- oxidizing agent usage, cure many because the free radicals breakage and output disease, as:Reduce cardiovascular with brain blood
Activity taken care of a pathological changes and repressed the Nuclear factor-κ B, repress DNA damaged and mutate, repress a carcinogen form
Become(reduce cancer occurrence), protecting the cell is free from radioactive ray injury and represses the liver toxicity accumulation and represses a year old form
The brain of becoming atrophies.
The following is the function that the AGE is used as anti- oxidizing agent:
1.The clearance ROS, the density of the increment GSH
2.Increase the density of the clearance free radicals enzyme(SOD, catalase, GSH peroxidase)
3.Repressing the fat leads to oxidize, the LDL oxidizes(protection inside the skin cell, become arteriosclerosis by arrestment)
4.Repress to is subjected to the NF-kB that the ROS activates(with the bottom line add to note for the back will mainly discuss of part)
And the AGE can regard as the function of the anti- oxidizing agent to come from:
Can clean up ROS, repress LDL to oxidize to lead to oxidize with fat
- The AGE can loot ROS up of electronics, reduce the formation free radicals
-Along with contain the S atom number increment in the sulphur composition, the ability increment of the clearance free radicals
2.Can promote the protection mechanism of the cell inner part
- The AGE can increase the GSH density in the cell effectively
- Strengthen the density of the clearance free radicals enzyme(SOD, catalase, GSH peroxidase)
- Repress the superoxide radical and H2 O2 formationses in the meantime
The major medicinal compound obtained from garlic is allicin, a powerful anti-biotic and anti-fungal.
Allicin does not occur in garlic naturally. Instead, garlic cloves contain the amino acid alliin (S-allylcysteine sulphoxide):
When garlic is crushed or otherwise damaged, the alliin reacts with the enzyme allinase, also found naturally in garlic. Allinase acts as a catalyst and results in the transformation of alliin into allicin (diallyl thiosulphinate):
Allicin begins to break down quickly, expecially if heated. Conversely its breakdown can be slowed by refrigeration.
When allicin degrades it produces various diallyl sulphides, the most common of which is diallyl dishulphide:
Although the diallyl sulphides do not have the strong anti-bacterial and anti-fungal properties of allicin, they are still believed to have medical benefits especially as regards circulation and cholesterol.
The garlic(garlic) produces a general situation brief introduction
The garlic is so called garlic, is the spring onion section plant, scientific term Allium sativum L., Good name Garlic, central Pamirs, original habitat Asia and China Mt. Heaven mountain range a bring.Garlic is ancient times was namely educated by the mankind to make use of of one of the ancient old crops, as early as 5,000 years, front there is namely the garlic cultivation in ancient Egypt it jot down, China at 2,000 year, front Han dynasty by piece the Qian introduces a cultivation from Western Regions, in Taiwan then from earlier period first people arrogance six introduce, also have more than 300 years to educate history.
The garlic and spring onion, ginger, Jiu, Xie match to call five Hs, cooking to deal with necessary fragrant and hot condiment.Garlic at caulis the leaf is soft and tender be called a green garlic, the flower stalk is called the garlic Tai, the underground department is gathered synthetic garlic ball by the garlic petal to be called garlic, canning be provided to eat.In addition to conduct and actions is fresh to season a vegetable to process to make into products, such as sugar vinegar Zi article, garlic slice, the garlic powder and the garlic oil Jing...etc. outside and fair.The garlic has the Allicins(the garlic vegetable) ingredient, having to disinfect, the health care result also is used for make medicine raw material.
Sperm immobilization activity of Allium sativum L. and other plant extracts
Kausiki Chakrabarti, Sulagna Pal, Asok K. Bhattacharyya
Aim: To identify possible spermicidal agents through screening a number of edible medicinal plants with antimicrobial activity.
Methods: Initial screening was made on the basis of ram cauda epididymal sperm immobilization immediately after addition of extracts. The most potent extract was selected and was evaluated on both ram and human spermatozoa. To unravel its mode of action several sperm functional tests were carried out, namely viability of cells, hypo-osmotic swelling test for membrane integrity and assays of membrane-bound enzyme 5?nucleotidase and acrosomal marker enzyme acrosin.
Results: The crude aqueous extract of the bulb of Allium sativum L. showed the most promising results by instant immobilization of the ram epididymal sperm at 0.25 g/mL and human ejaculated sperm at 0.5 g/mL. Sperm immobilizing effects were irreversible and the factor of the extract responsible for immobilization was thermostable up to 90 ℃. On boiling at 100 ℃ for 10 minutes, this activity was markedly reduced. Moreover, this extract was able to cause aggregation of ram sperms into small clusters after 30 minutes of incubation at 37 ℃. However this property was not found in human spermatozoa. More than 50 % reduction in sperm viability and hypo-osmotic swelling occurred in treated sperm as compared with the controls, indicating the possibility of plasma membrane disintegration which was further supported by the significant reduction in the activity of membrane bound 5?nucleotidase and acrosomal acrosin. Conclusion: The crude aqueous extract of A. sativum bulb possesses spermicidal activity
1 Introduction
There are many Indian medicinal plants, which were reported to possess antifertility property; they acted either by preventing implantation or by suppressing spermatogenesis [1, 2]. The most potent spermicidal agent presently available in the market was a formulation of nonoxynol-9, however the product had been observed to cause inflammation and genital ulceration and thereby increased the risk of HIV-1 infection on repeated use [3, 4]. On the other hand, gossypol, a seed extract of Chinese cotton plant Gossypium herbaceum, was studied extensively but the programme was discontinued due to its side effects, mainly hypokalaemia [5]. Considering these problems, the present investigation had been carried out on screening a number of edible medicinal plants, namely Allium sativum (family Lilliaceae), Zingiber officinale (Zingiberaceae), Curcuma longa (Zingi-beraceae), Curcuma amada (Zingiberaceae), Allium cepa (Lilliaceae) and so forth at an aim to identify active extracts for the future development of herbal spermicidal agents.
2 Materials and methods
2.1 Test materials
Ram testes were obtained from slaughterhouse in the local market and human ejaculates, from the Scientific Clinical Research Laboratory Pvt. Ltd. (Kolkata, India). Plant materials were collected from the local market. a-N-benzoyl-L-arginine ethyl ester (BAEE), HCl and adenosine 5’-monophosphate sodium salt were purchased from Sigma (St.Louis, USA) and other chemicals, from E-merck (Germany).
2.2 Preparation of sperm suspension
For ram sample, the cauda portion of epididymes was isolated and minced in 0.9 % saline solution (pH 7.5) and filtered through a piece of cheese cloth to get sperm suspension. For human sample, ejaculates (n=10) from normal subjects after 72 h~96 h of sexual abstinence were subjected to routine semen analysis following liquefaction at 37 ℃. Sperm count above 100 million/mL and viability above 60 % with normal morpho-logy, rapid and progressive motility was employed for the tests.
2.3 Preparation of plant extract
The fresh plant materials, Allium sativum bulb, Zingiber officinale stem, Curcuma longa stem, Curcuma amada stem and Allium cepa bulb, were homogenized separately with the help of a mortar in physiological saline (pH 7.4). Homogenates were centrifuged at 10,000 ×g at 4 ℃ for 30 minutes. The pellet was discarded and the supernatant was preserved at 4 ℃ for experimental purposes.
2.4 Immobilization assay
Crude extracts of the plants and either ram epididymal sperm suspension (100 million/mL~200 million/mL) or human ejaculate (100 million/mL~150 million/mL) were mixed thoroughly in 1:1 ratio according to a modified method of Waller [6]. A drop of the mixture was placed immediately on a slide and at least five fields were microscopically observed under high power (×400) for assessment of sperm motility. The mixture was then incubated at 37 ℃ for 30 minutes and the above process was repeated.
2.5 EC50 determination
The effective concentration that causes 50 % immobilization of highly motile cells (EC50) [7] was determined by different dilutions of garlic extract using physiological saline as the dilution medium. Sperm suspension and garlic extract were mixed in 1:1 ratio. The concentrations ranged from 0.25 g/mL to 0.8 mg/mL for ram epididymal sperm and 0.5 g/mL to 0.11 g/mL for human ejaculated sperm .
2.6 Nonspecific aggregation estimation
Different concentrations of Allium sativum (ranging from 0.25 g/mL to 0.8 mg/mL) were treated with ram sperm suspension in 1:1 ratio and kept at 37 °C for 1 h. Then from the bottom of the microcentrifuge tube, one drop of the sedimented sperm was placed on a slide and the percent aggregation was examined microscopically under ×400 magnification. Considering that the non-aggregated spermatozoa will remain in the supernatant, the latter was collected and the turbidity determined spectrophotometrically [8] at 545 nm. This experiment was not performed with human ejaculates, as human sperm did not show any sign of aggregation after incubation with the plant extract.
2.7 Extract stability evaluation
Crude extract was heated in water bath at different temperatures (30 ℃, 50 ℃, 70 ℃, 90 ℃ and 100 ℃) and aliquot was taken, cooled and centrifuged. The supernatant and the pellet were kept separately. The supernatant was tested for its effect on the sperm motility and the pellet was similarly tested after resuspended in physiological saline. The crude extract was lyophilized and the residue resuspended in physiological saline. It was then centrifuged to discard undissolved matter, if any. The clear supernatant was again tested microscopically as described earlier and the loss of activity was re-corded.
2.8 Sperm revival test
After completion of the experiment, the spermatozoa were washed twice in physiological saline and incubated once again in the same medium free of plant extract at 37 ℃ for 30 minutes to observe the reversal of sperm motility.
2.9 Assessment of plasma membrane integrity
Sperm viability and hypo-osmotic swelling (HOS) tests were done according to WHO [9], Eliasson & Treichl [10] and Jeyendran et al. [11] for assessing plasma membrane functional integrity. Ram sperm suspension (100 million/mL~200 million/mL) and human ejaculated sperm (100 million/mL~150 million/mL) were mixed separately with Allium sativum extract at the minimum effective concentration i.e., 0.25 g/mL and 0.5 g/mL, respectively at a ratio of 1:1 and incubated for 30 min at 37 ℃. Similarly, sperm samples in saline served as the controls. For viability assessment one drop each of 1 % aqueous solution of eosin Y and of 10 % aqueous solution of nigrosin was placed in a microcentrifuge tube. A drop of well mixed sperm sample was added to it and mixed thoroughly. The mixture was dropped onto a glass slide and observed under ×400 magnification. For HOS 0.1 mL of aliquot was taken from each of the treated and control sample, mixed thoroughly with 1mL of HOS medium (1.47 % fructose and 2.7 % sodium citrate at 1:1 ratio), incubated for 30 minutes at 37 ℃ and the curling tails were examined under phase contrast microscope using ×100 magnification.
The activity of 5’-nucleotidase was determined by measuring the rate of release of inorganic phosphate from adenosine 5’-monophosphate according to Heppel and Hilmoe [12] with a minor modification in substrate concentration as standardized in our laboratory. After incubating the sperm suspension with the plant extract, the sperm pellet was collected by centrifugation at 3,000 g at 37 ℃, washed twice in 0.9 % saline and then suspended in 0.1 mol/L Tris-HCl buffer (pH 8.5) with each reaction system containing (100~200) million sperma-tozoa. An aliquot of 0.1mL suspension of sperm was added to 0.9 mL of buffered substrate containing 3 mmol/L adenosine 5’-monophosphate and 50 mmol/L MgCl2 dissolved in 0.1 mol/L Tris-HCl buffer. The tubes were incubated at 37 ℃ for 30 minutes and 0.5 mL 20 % TCA (0 ℃~4 ℃) was added to the mixture to stop the reaction. The mixture was then centrifuged at 10,000 ×g at 4 ℃. The pellet was discarded and the supernatant was kept for phosphate estimation [13]. The activity of 5’-nucleotidase was expressed in terms of μg of phosphate released.(hour.108 cells)-1.
2.10 Evaluation of acrosomal status
The most widely studied acrosomal enzyme is the acrosin that has been shown to be associated with acrosomes of all mammalian spermatozoa and the highest substrate specificity was obtained with BAEE. The pellets were extracted with 3 mmol/L HCl at pH 3 and the enzyme activity was measured according to Bhatta-charyya, et al. [14, 15] following the hydrolysis of 0.5 mmol/L BAEE dissolved in 0.05 mol/L Tris HCl buffer containing 0.05 mol/L CaCl2 at pH 8. The activity of acrosin was expressed in terms of mIU.(min.108 cells)-1. One mIU activity means the amount of enzyme, which caused the hydrolysis of one nanomole of BAEE in one minute at 25 ℃.
2.11 Statistical analysis
Data were expressed in mean±SEM. Student’s t-test was employed for statistical comparison.
3 Results
3.1 Sperm immobilization and aggregation
The crude extracts of all the five plants at 1 g/mL concentration level were able to immobilize the ram spermatozoa instantly. A. sativum crude extract was the most effective and a concentration of 0.5 g/mL was able to immobilize human spermatozoa instantly at 1:1 ratio.
showed the relative efficacy of the extracts at the minimum effective concentration of 0.25 g/mL and Figure 2, the EC50 values of A. sativum extract with ram (0.01 g/mL) and human (0.16 g/mL) spermatozoa. The data on nonspecific aggregation of ram spermatozoa were not presented but it suggested that the higher the concentration of A. sativum extract, the greater the percent of sperm aggregation and the less the optical density of isolated sperm floating in the supernatant.
Figure 1: In vitro effect of aqueous extract of five medicinal plant parts on motility of goat cauda epedidymal spermatozoa at a concentration of 0.25 g/mL.
Figure 2: EC50 of A. sativum extract with ram epididymal sperm (triangles) and human ejaculated sperm (circles).
3.2 Extract stability
The supernatant of A. sativum showed 100 % immobilization (both with ram and human sperm) on heating up to 90 ℃, but its sperm immobilization activity was reduced to 60 % (ram epididymal sperm) or 70 % (human sperm) after boiling for 10 minutes at 100 ℃. The pellet obtained from each fraction, when resuspended in physiological saline, did not show immobilization activity. Crude extract at room temperature (23 ℃~ 26 ℃) was able to aggregate ram spermatozoa, but on heating (50 ℃~100 ℃) none of the aliquots showed this property. After lyophilization of the crude extract, the sperm immobilization property remained unaltered, but the ram sperm aggregation property was lost.
3.3 Sperm revival test
None of the spermatozoa, once immobilized, recovered their motility following removal of plant extracts and 30 minutes incubation with physiological saline.
3.4 Serm membrane integrity
The significant decrease in sperm viability on treatment with the extract indicated the spermicidal property of A. sativum crude preparation. Ram as well as human spermatozoa showed typical morphological changes when subjected to hypo-osmotic shock. These changes were clearly visible by phase contrast microscopy. In our experiment, the controls showed the maximum amount of tail curling, while in A. sativum extract treated sperma-tozoa, tail curling was significantly reduced (P<0.01), indicating the impairment of functional integrity of the plasma membrane. From Table 1, it could be seen that the release of inorganic phosphate was the maximum in the controls and was significantly reduced in the treated group, indicating inactivation and/or maximum expulsion of the enzyme 5’-nucleotidase following A. sativum extract treatment and thereby hampering the breakdown of the substrate by the enzyme which is known to be plasma membrane associated. A similar result was obtained with acrosin, indicating the vesiculation or perforation of membrane system.
Table 1. Effect of A. sativum extract in vitro (n=10). All values are statistically significant (P<0.01) in comparison to controls. Sp.Sus. = Sperm suspension; P.Ext. = Plant Extract.
|
|
Ram cauda epididymal sperm |
Human ejaculated sperm |
||
|
Control |
Treated |
Control |
Treated |
|
|
Viability (%) |
77.00±5.66 |
21.33±4.72 |
67.50±6.09 |
32.00±2.92 |
|
HOS (%) |
67.83±5.49 |
19.43±4.50 |
68.00±3.00 |
18.00±5.50 |
|
5'-nucleotidase |
6.54±1.14 |
1.64±0.62 |
6.52±1.37 |
3.24±0.63 |
|
Acrosin |
280.20±32.60 |
160.25±19.30 |
331.25±76.60 |
120.35±18.25 |
4 Discussion
Farnsworth and Waller [16] have screened a large number of plants for spermicidal property and reported that the majority of plant-derived spermicides were triterpene saponins of several structural types, flavonoids and phenol compounds. The saponins of Cyclomen persicum, Primula vulgaris and Gypsophyla paniculata have been reported to cause almost instant immobilization of human spermatozoa within 20 seconds [17]. Carica papaya seed extract has also been shown to possess sperm immobilizing effect in human spermatozoa in vitro [18]. The purified fraction from the aqueous crude extract of Echeveria gibbiflora had sperm immobilizing activity as well as strong agglutinating property in guinea-pig spermatozoa [19].
The present paper here reported for the first time the sperm immobilization activity of the aqueous homogenate of five edible plant parts having antimicrobial activities [20]. A. sativum extract was shown to be the most active. It was indicated previously that allitridum, an active principle of A. sativum, showed spermicidal effect on rat and hamster spermatozoa [21]. The present study pointed out that at a concentration of , A. sativum crude aqueous extract was able to immobilize human spermatozoa instantly. The extract of A. sativum contained certain sperm agglutination factor as it agglutinated the ram epididymal spermatozoa, however, the human sperm in the presence of seminal fluid were not agglutinated.
Most of plant spermicidal compounds act on the sperm surface, disrupting the plasma membrane [16]. The currently used active principle of vaginal spermicide, nonoxynol-9, acted in a similar manner. It produced disruption of lipids within the sperm membrane, par-ticularly, on the acrosome and mid-piece causing rapid loss of sperm motility [22, 23]. Inhibition of sperm specific enzymes, as acrosin and hyaluronidase, which play important roles in the fertilization process, by plant derivatives has also been reported [16].
In the present study the damage to the membrane architecture was evidenced by the significant reduction in sperm viability and tail curling and a marked decrease in the 5’-nucleotidase and acrosin activities in the treated group. A property of the cell membrane was its ability to permit the transport of molecules selectively. This is not only essential for the maintenance of sperm motility, but also for the induction of the acrosome reaction and possibly other key events related to fertilization [11]. When exposed to hypo-osmotic conditions, water will enter the spermatozoon in an attempt to reach osmotic equilibrium, and as a result the sperm volume increased and plasma membrane bulges. This ability of spermatozoa implied intact membrane function. On incubation of motile sperm with A. sativum extract this general property of the plasma membrane was lost, and moreover, the plasma membrane marker enzyme 5?nucleotidase was also getting released, possibly due to disstabilization of plasma membrane. The loss of acrosin from the acrosomal structure also indicated the damage of at least the outer acrosomal membrane with plant extract treatment. What we have attempted to show here, however, was that aqueous extract of very commonly used edible bulbs of A. sativum possess a potent sperm immobilizing/ spermicidal factor which is thermostable up to 90 ℃. The mode of action appeared to involve the disruption of membrane architecture leading to the release of membrane associated key molecules, thereby causing impairment of functional competence of the cells.
Acknowledgements
The work has been done under partial financial support of Indian Council of Medical Research, New Delhi and University of Calcutta. Authors are thankful to Dr. S. K. Datta (Scientific Clinical Research Laboratory Pvt.Ltd. Kolkata.) for supplying human samples.
The research of the Epidemiology finds the complement of the fish oil will change the probability of the heart disease occurrence, and the garlic then will influence three density of the sour glycerin esters inside the body.The purpose of this article experiment is after studying to combine the fish oil and garlic as everyday dietetic supplement, whether will influence fat of basal metabolism.40 test-receivers of blood fat abnormalities(the total cholesterol is big in the 200 mgs/dl) participate this list blind, hand over with each other an experiment of using the placebo. Each test-receiver accepts for the period for a month respectively, giving everyday placebo or give the fish oil(the 1800 mg EPA+the 1200 mg DHA) enlargement garlic(1200 mgs) capsule(the body treasure is rather) complementary experiment. Add placebo for a month and add the fish oil enlargement garlic capsule(the body treasure rather) while testing beginning a measurese test-receiver's blood respectively after month in fat of constitute cent and take into compare. Test a period, the test-receiver maintains an original food habit.
Found 40 test-receivers were after adding the fish oil enlargement garlic capsule(the body treasured rather) a month equally reducing blood cholesterol 11% as a result always and three the sour glycerin esters are 34%s, reducing the low density fat egg white cholesterol 10%, reducing the specific value of the cholesterol and the high definition fat egg white cholesterol about 19%, and the density of the slight exaltation high definition fat egg white cholesterol. Then have no obvious influence after giving the placebo complement.
This research result shows that in addition to all having the characteristic that the anti- Ning blood and anti- oxidize, the fish oil and garlic combine the fish oil and garlic, both are the nourishments supplement to add a wills change a fat set inside the body after month Basal metabolism of becoming, it is to the influence of three sour glycerin esters to is the biggest particularly. Because the complement of the fish oil enlargement garlic capsule(the body treasure rather) can reduce total cholesterol of blood, and reduce the specific value of the cholesterol and the high definition fat egg white cholesterol; Therefore think, the complement of the fish oil enlargement garlic capsule(the body treasure rather) really can reduce to contract cardiovascular disease of chronic brain effectively of dangerous factor.
Garlic by contain of the methane garlic Ji three function of the sulphide(the methyl allyl trisulfide)s reduce blood vessel to press, this material can extend the tube wall.The garlic can make the blood become sparse, can turn down the probability of the blood Ning piece, and have already helped the prevention heart attack thus. It can also reduce the density of the serum cholesterol, and the help digest. The garlic is been used for a lot of treatments of diseases to include cancer.It is a valid immune system accelerant. The person of Su E calls the garlic is a natural antibiotics. Should take it everyday, also have a great deal of garlic vegetable. its main composition is the volatility sulphide, it has something to do with the mordacious flavor of the garlic.
The garlic vegetable has the effect of the antibiotics Its anti-virus function is 1% of the penicillin antibiotics.Because the garlic contain this characteristic, during the period of World War I, it is used once to cure the wound and infection, and prevent bad Ju(gangrene).
The garlic vegetable is a kind of volatility plant alexin.The medicine of the garlic uses, being all having long history at home and abroad.Ancient Greece athlete have ever used garlic as to care a food:The Pu benefit Ni of ancient Rome have ever caught a cold with the garlic treatment, asthma, measles etc. disease, obtain a difference usually of result:India doctor finds again to often eat garlic and can make the intelligence strengthen, the voice is loud and clear.
Beauty Benefits
Reduce blood pressure effectively, the cholesterol and the anti- Ning blood, arrange poisonous and pure blood.through the experiment certificate:It can resist a staphylococcus, salmonella effectively, the cholera Hu germ, the dysentery rod bacteria, the typhus germ, fungi etc. the cause microorganism of the variety.it can cure the nose mucosa Yan, catching a cold, bronchitis, tuberculosis, whooping cough, lead poisoning, the glycouria is far-gone. enrich to contain an iron, vitamin and have the antibiosis of the geniality.
Mainly can prevent decreasing swelling, improve an allergic skin.Usually is used in a manufacture a health care the capsule product, the most well-known in order to resist the function of the high blood pressure, and strengthen immune system function.
Have the anti- Yan compound, can defend the outbreak of the allergy.